Synthesis of anti-tumor dimeric indole alkaloids in catharanthus roseus was promoted by irradiation with near-ultraviolet light at low temperature.
نویسندگان
چکیده
We have found that coupling between catharanthine and vindoline occurs non-enzymatically in the presence of flavin mononucleotide and manganese ions with near-ultraviolet light irradiation in vitro. The present study found that the concentrations of catharanthine and vindoline in Catharanthus roseus decreased and those of dimeric indole alkaloids increased under near-ultraviolet light at 4 degrees C. It indicates that this coupling reaction at 4 degrees C occurs non-enzymatically.
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ورودعنوان ژورنال:
- Bioscience, biotechnology, and biochemistry
دوره 74 2 شماره
صفحات -
تاریخ انتشار 2010